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Our study did not detect the case and control groups in plasma TGF-pl average

dimanche 30 septembre 2012 à 02h32:28 GMT -4.00

 Our study did not detect the case and control groups in plasma TGF-pl average, so we can not judge the case group and the control group, TGF pl level differences, and at the same time we can not analyze the SNP loci of studyTGF-pl expression level of the object plasma reason: physiological circumstances, TGF pl level is mainly affected by the impact of genetic mechanisms [24] TGFBI a 509c> TsNP can affect the level of serum TGF-pl [26]therefore, in the study, but the incidence of stroke, under stress, TGF pl level may be affected, and that we will not be able to analyze the changes in the levels of TGF-pl or stroke before the stroke, we did not analyze differentgenotype expression level and activity of TGF-pl. Our research has not found a 509C&

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Taking into account the role of genetic factors in the incidence of stroke and TGF pl level is mainly affected by the impact of the genetic mechanisms down

lundi 10 septembre 2012 à 02h06:28 GMT -4.00

 In our experimental design, in order to minimize selection bias, we selected cases and control subjects from Changsha, the case and control groups were strict gender, age-matched, in the analysis of a 509C> T genotype on the stroke affect, logisti. Regression, multivariate analysis was performed to minimize the impact of the results of the analysis of traditional stroke risk factors such as age, sex, hypertension, diabetes, hyperlipidemia, smoking, alcohol consumption, in the relationship of +869 T> C and stroke we use the same method. The results show that a SOgC> TSNP occur no significant correlation between cerebral infarction and cerebral hemorrhage in Changsha Han population. However, taking into account the role of genetic factors i

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Very little reported about of the sNP lipid metabolism between specific mechanism needs further study

jeudi 06 septembre 2012 à 03h24:34 GMT -4.00

 In our study, the the cI, cH and control group were divided into AP (carotid plaque) group, WAP (without carotid plaque) group and H group (hypertension group), and wH (non-highblood pressure) group, the more we have not found a sooG> a polymorphism and carotid artery plaque stability correlation not found a 800G> A polymorphism with hypertension or non-hypertensive patientsstroke significantly related. In our study did not find a 800G> A polymorphism and the formation of carotid artery plaque Changsha Han population, hypertension was significantly related. Analysis CI group, CH and control groups within each group different genotype TG, TC, HDL, C and LDL-C average, we found that in the three groups, the A allele compared with GG genotyp

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More research on TGFBI 09c> TsNP with coronary heart disease and myocardial infarction

jeudi 30 août 2012 à 14h40:32 GMT -4.00

 At present, more research on TGFBI 09c> TsNP with coronary heart disease and myocardial infarction. wang in a 509C> T polymorphism in the TGF 371 patients with coronary heart disease, did not find a 509C> the TSNP with coronary artery over 50% stenosis related. Rotterdam, the Netherlands [28] found a 509c> TsNP no significant correlation with myocardial infarction. Nor found a 509c Kochw [77], etc.> TsNP by coronary angiography confirmed myocardial infarction was significantly related, but in the male, the CC genotype myocardial infarction prevalence was 0.49 times of the T allele, the the Cc gene on the occurrence of myocardial infarction is a protective factor, found no such relationship, that due to differences in estrogen levels in women; s division sP [78l rese

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TGFBI a S09C> T and stroke in Changsha Han population

lundi 27 août 2012 à 04h33:56 GMT -4.00

 A 509C> T, also known as c 1347C> TSNP TGFBI the negative regulator components. A study of twins, a 509T homozygous individuals plasma level of TGF-pl is almost twice the 509c homozygous 1251, numerous studies have confirmed that the 509T allele (which can lead to increased levels of TGF-pl) with the invasion and metastasis of breast cancer, Alzheimer's disease, severe asthma and breast cancer patients radiotherapy fibrosis and other complex diseases due to the severity, progression and prognosis are closely related. About All a soge> T polymorphism of TGFBI gene expression little impact studies. There are the three study detected by EMSA technology the function of 509c> TsNP, remains unclear but about the sNP the molecular mechanisms

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